A new study from the University of Illinois at Chicago reveals multiple genetic variants associated with vertical cup-to-disc ratio (VCDR), when combined to create a genetic risk score (GRS), may be useful predictors of primary open-angle glaucoma (POAG) in a Latino population.

The researchers recruited 4,018 Latino participants to analyze the possible association between GRS and VCDR. They created the genetic risk score based on 68 previously reported VCDR single nucleotide polymorphisms (SNPs), as well as SNPs from the researchers’ own genome-wide association data. After adjusting for age, gender, central corneal thickness, intraocular pressure and education, the researchers note a significant association between the GRS and VCDR in the participant population. The data also shows the GRS’s improved discriminatory ability for POAG when using previously reported SNPs.

“To our knowledge, we identified a novel association between GRS and VCDR and its improvement in the discriminatory ability of POAG in a Latino population,” the researchers conclude. 

Nannini DR, Kim H, Fan F, Gao X. Genetic risk score is associated with vertical cup-to-disc ratio and improves prediction of primary open-angle glaucoma in Latinos. Ophthalmology. 2018;125(6):815-21.