Understanding these features may help disease diagnosis in Asian populations. Patients with the former subtype were significantly younger, predominantly male and had a slower progression rate.
Progression is positively associated with non-exudative subretinal fluid and hyperreflective material as well as iRORA. It’s negatively associated with retinal pseudocysts and subfoveal choroid thickness.
After 24 months of treatment with oral minocycline, participants showed no significant decrease in lesion enlargement rate. Mild and moderate AEs were also common.
The metrics could lead to future clinical trials that better characterize both the natural history of the disease as well as early treatment response, the authors suggest.
Study finds GA patients with a reabsorbed PED have significant visual deficits and may not benefit from new treatments aimed at inhibiting the complement system, as the mechanism is different.