Researchers recently identified potential risk factors associated with the development of severe dry eye disease (DED) in patients with ocular graft-vs.-host disease (GVHD).

This retrospective chart review evaluated 78 post-transplant DED patients with GVHD. They were a median age of 56 years old and half were male.

The investigators reported a median Schirmer score of 14mm (0mm to 25mm). They noted that a lower Schirmer score, severe overall chronic GVHD and lung involvement were associated with worsening DED in GVHD.

Of the total participants, the researchers observed 17.95% with severe DED. Compared with those with less severe DED, they added that this group was more likely to be male and have a lower Schirmer score, significantly worse overall chronic GVHD and lung and gastrointestinal tract involvement.

Wang JCC, Mustafa M, Teichman J, et al. Risk factors associated with severity of dry eye syndrome in ocular graft-versus-host disease. Can J Ophthalmol. May 18, 2020. [Epub ahead of print].