Researchers recently identified potential risk factors associated with the development of severe dry eye disease (DED) in patients with ocular graft-vs.-host disease (GVHD).
This retrospective chart review evaluated 78 post-transplant DED patients with GVHD. They were a median age of 56 years old and half were male.
The investigators reported a median Schirmer score of 14mm (0mm to 25mm). They noted that a lower Schirmer score, severe overall chronic GVHD and lung involvement were associated with worsening DED in GVHD.
Of the total participants, the researchers observed 17.95% with severe DED. Compared with those with less severe DED, they added that this group was more likely to be male and have a lower Schirmer score, significantly worse overall chronic GVHD and lung and gastrointestinal tract involvement.
|Wang JCC, Mustafa M, Teichman J, et al. Risk factors associated with severity of dry eye syndrome in ocular graft-versus-host disease. Can J Ophthalmol. May 18, 2020. [Epub ahead of print].|