Geographic atrophy

Two Studies Give Positive Marks to Pegcetacoplan Therapy for GA

Real-world results show that the drug reduced annual growth rate by about 34%. A clinical trial extension also reported a similar level of efficacy.

Similarities and Differences Between Pachychoroid GA and Conventional GA Identified

Understanding these features may help disease diagnosis in Asian populations. Patients with the former subtype were significantly younger, predominantly male and had a slower progression rate.

Study Finds Imaging Biomarkers Associated with GA Growth Rate

Progression is positively associated with non-exudative subretinal fluid and hyperreflective material as well as iRORA. It’s negatively associated with retinal pseudocysts and subfoveal choroid thickness.

Pachydrusen in AMD Eyes Raises Risk of MNV but Not GA

This is especially the case when macular pigmentary changes are also present, study finds.

Investigative GA Drug Fares Poorly in Phase II Trial

After 24 months of treatment with oral minocycline, participants showed no significant decrease in lesion enlargement rate. Mild and moderate AEs were also common.

Investigational Subretinal Implant Could Help Restore Vision Loss from GA

Device seeks to mimic photoreceptor function and re-enable retinal neurons. Three subjects gained at least four ETDRS lines in recent tests.

Thin Double Layer Sign in the Fovea on OCT Predicts GA

Structural imaging shows the presence of biomarkers associated with the development of foveal atrophy at two years.

AMD Genetic Profile Predictive of Early GA Enlargement

ARMS2/HTRA1 is an important risk factor for identifying eyes likely to experience fast lesion progression.

New GA Drug from Iveric Bio Approved

Clinical trials show Izervay can slow disease progression with as few as six monthly doses.

Novel Microperimetry Endpoints Better at Detecting Functional Decline in GA

The metrics could lead to future clinical trials that better characterize both the natural history of the disease as well as early treatment response, the authors suggest.

Upcoming Events

June 26, 2024

Patient-Centered Communications: Practical Strategies for Discussing EVO ICL
Location: Virtual
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