Choroidal neovascularization (CNV) activity in AMD is traditionally assessed with clinical parameters, fundus fluorescein angiogram and spectral-domain OCT (SD-OCT). To explore other monitoring methods, a research team evaluated the ability of OCT-angiography (OCT-A) in detecting CNV progression.

The study included 152 eyes of 106 patients with AMD (59 eyes with wet AMD and 93 eyes with dry AMD and high-risk drusen). Patients were assessed for disease activity with the three traditional methods, as well as OCT-A. Compared with traditional methods, OCT-A had 85.4% specificity and 79.3% sensitivity in determining the presence or absence of CNV. OCT-A had a 69.5% accuracy in determining active CNV and resulted in false positives and negatives 21.6% and 8% of the time, respectively.

The authors concluded that en-face OCT-A images provide only a moderate ability in identifying CNV. “OCT-A alone is weak at recognizing active CNV requiring treatment in AMD,” they stated.

Cavichini M, Dans KC, Jhingan M, et al. Evaluation of the clinical utility of optical coherence tomography antiography in age-related macular degeneration. Br J Ophthalmology. August 21, 2020. [Epub ahead of print].