A new study found a correlation between the number of hyper-reflective particles in the anterior chamber (AC) after SLT and the procedure’s IOP-lowering effect.

This prospective interventional study included 25 eyes of 25 primary open-angle glaucoma patients. All participants underwent standardized SLT consisting of 100 pulses of 0.9mJ over 360°. A team performed anterior segment OCT and applanation tonometry before SLT and 15 minutes, one day, one week, one month and three months after. They then counted particles on cross-sectional scans.

With a baseline IOP of 21.4±4.5mm Hg, the researchers recorded post-op IOPs at months one and three of 18.0±4.0mm Hg and 17.4±3.3mm Hg, respectively. They noted that the mean numbers of AC particles before and 15 minutes after SLT were 0.62±0.2particles/mm2 and 7.1±2.0particles/mm2, respectively. The correlation between the mean number of AC particles 15 minutes after SLT and IOP reduction at one and three months was statistically significant, they added.

Kulikov AN, Maltsev DS, Kazak AA, et al. Anterior chamber particles are associated with reduction of intraocular pressure after selective laser trabeculoplasty. Br J Ophthalmol. February 12, 2020. [Epub ahead of print].