Researchers in Mexico propose that adding antibiotics to the fluid reservoir of scleral lenses could be an effective and comfortable infectious keratitis treatment option. They observed no complications or side effects related to the use of the scleral contact lens as a reservoir for moxifloxacin.

In 12 eyes of 12 patients with infectious keratitis, the study used a scleral lens filled with 0.5% moxifloxacin as a reservoir and replaced it every 24 hours until epithelization was complete or the culture report and/or antibiogram demonstrated either a microorganism not susceptible or resistant to moxifloxacin. All patients completed at least one month of follow-up.

Of the 12 eyes, seven had culture-positive bacterial infection, two eyes were mycotic and three eyes had no culture growth. The study discontinued scleral lenses in three eyes because of the lack of response (one eye) and due to the presence of mycotic infection (two eyes). Still, all infections resolved favorably at the final follow-up.

The study concluded that the treatment modality ensured good impregnation and maintenance of antibiotic concentrations during the 24-hour wear periods.

Polania-Baron EJ, Santana Cruz O, Lichtinger A, et al. Treatment of severe infectious keratitis with scleral contact lenses as a reservoir of moxifloxacin 0.5%. Cornea. August 24, 2020. [Epub ahead of print].